Abstract
Biosensors based on optical detection such as the Surface Plasmon Resonance (SPR) and Resonant Mirror (RM) systems show great promise in the specific detection of bacteria, viruses and toxins. These techniques monitor the changes in refractive index when an analyte binds to a recognition element immobilised on the sensor surface. The binding of the agent is measured directly resulting in rapid response times. The assays need only a single reagent coupled to the optical surface. In contrast, most other transduction systems require the further addition of a second antibody labelled with an enzyme, fluorophore, or some other tag to make the binding event detectable. These SPR and RM devices are compact with simple fluidics, have no moving parts and are easy to ruggedise. Multi-analyte monitoring should be possible with multiple detection spots on the optical surface, each with specificity for a different analyte or as controls.
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