Biosensors and Nanodevices Based on DNAzymes

Wang Lihao,Jie Guifen,Wang Jialin

doi:10.35840/2633-8912/2407

Abstract

This review mainly report the principle and development of biosensors and nanodevices based on DNAzymes, including fluorescent DNAzyme biosensor, colorimetric DNAzyme biosensor, Surface Enhanced Raman Scattering (SERS) DNAzymes biosensor, electrochemical DNAzymes biosensor, and catalytic biosensor using DNAzymes as signal amplifiers.

Highlights

Biosensor is an analytical device that can quickly make a reversible response, it uses bioactive materials (such as enzymes, proteins, DNA, antibodies, antigens, biofilms, etc.) as detection substances, and combine various means such as chemistry [1], physics, medicine and electronic technology to achieve the purpose of detection
Biosensor is an analytical device that can quickly make a reversible response, it uses bioactive materials as detection substances, and combine various means such as chemistry [1], physics, medicine and electronic technology to achieve the purpose of detection
DNA origami technology offers the possibility of instruments with resolution below 10 nm, which provide a new way to inspire the precise design of nanostructures

Summary

Introduction

Biosensor is an analytical device that can quickly make a reversible response, it uses bioactive materials (such as enzymes, proteins, DNA, antibodies, antigens, biofilms, etc.) as detection substances, and combine various means such as chemistry [1], physics, medicine and electronic technology to achieve the purpose of detection. The high flexibility of the binding arm design, the superiority of substrate recognition and multiple enzymatic conversion properties make DNAzymes have universal recognition and excellent signal amplification in biosensing, and promise for mRNA targeting, DNAzymes therapy. An identification device that selectively binds to the target molecule and a sensor device that converts the recognition activity into a detectable signal.

Results

Conclusion