Abstract
Tetrathiafulvalene(TTF) was doped in an SiO 2 network and the resulting nanocomposite was used as a mediator for the selective detection of glucose. The uniform TTF-doped silica(TTF@ SiO 2 ) nanoparticles were prepared by the water-in-oil(W/O) microemulsion method, and were characterized by transmission electron microscopy(TEM). The core-shell structure TTF@ SiO 2 could prevent TTF from leaching out into an aqueous solution. Combined with chitosan(CHIT), which serves as a scaffold for glucose oxidase and nanocomposite immobilization, the GCE/TTF@ SiO 2 -CHIT-GOx biosensor was developed. Under optimal conditions, the biosensors exhibit a linear range of 1.0 × 10 −5 –5 × 10 −3 mol/L with a detection limit down to 5.0 μmol/L( S/N = 3). The excellent selectivity, sensitivity, and stability of the glucose biosensor show its potential for practical applications.
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