Abstract
Graphene is suitable material for sensors because of high mobility and chemical stability. Recently graphene field effect transistors (FETs) have been applied for sensitive bio-sensors. In graphene FET bio-sensors, biomaterials are detected by changes of graphene electrical properties. However, Graphene FET biosensors cannot electrically detect targets which do not change electric characteristics of graphene. Here, we focused on open sandwich immunoassay which is antigen-antibody complex reaction by two antigen binding fragments (VH and VL). If VH are modified on graphene and detectable materials like ions were modified on VL, undetectable antigens can be detected. In this study, we have demonstrated sensitive detection of small peptides which is difficult to detect directly in graphene FETs and selectively detected using open sandwich immunoassay.
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