Abstract
Aerolysin-based direct analysis of oligonucleotides with secondary structure (e.g., G-quadruplex) remains a challenge. In article number 1704520, Yi-Lun Ying, Yi-Tao Long, and co-workers present a strategy employing an aerolysin nanopore to analyze structured oligonucleotides that are extended to 30 bases in length by a cation-regulation mechanism. This method can in principle be applied to genetic and epigenetic biosensing, making it practical for diagnostics.
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