Abstract
Covered self-expandable metal stents (CSEMS) are often used for palliative endoscopic biliary drainage; however, the unobstructed period is limited because of sludge occlusion. The present study aimed to evaluate the biosafety of a novel poly(2-methoxyethyl acrylate)-coated CSEMS (PMEA-CSEMS) for sludge resistance and examine its biosafety in vivo. Using endoscopic retrograde cholangiopancreatography, we placed the PMEA-CSEMS into six normal porcine bile ducts and conventional CSEMS into three normal porcine bile ducts. We performed serological examination and undecalcified histological analysis at 1, 3, and 6 months during follow-up. In the bile ducts with PMEA-CSEMS or conventional CSEMS, we observed no increase in liver enzyme or inflammatory marker levels in the serological investigations and mild fibrosis but no inflammatory response in the histopathological analyses. Thus, we demonstrated the biosafety of PMEA-CSEMS in vivo.
Highlights
Curative resection can be performed in
The poly(2-methoxyethyl acrylate) (PMEA)-Covered self-expandable metal stents (CSEMS) were placed in six of the nine pigs, the conventional CSEMS were placed in three pigs, the Uncovered self-expandable metal stents (USEMS) was placed in one pig, and no stent was placed in another pig
The six animals with PMEA-CSEMS were divided into three groups of two pigs each, and a different group underwent blood collection and necropsy under the same sedation conditions as those for pretreatment at 1, 3, and 6 months (PMEA-CSEMS group)
Summary
Curative resection can be performed in
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