Abstract
A biosafety study was carried out concerning the metabolites of Streptomyces tauricus strain 19/97 M. This strain is a promising producer of biological preparations and shows antagonistic properties against Fusarium fungi, which cause Fusarium wilt disease. The strain has a pronounced biological activity against conifers, cereals and legumes. The treatment of planting material reduces infections, increases germination and furthers plant productivity. Using metabolites, we understood the culture liquid separated by filtration after the cultivation of the strain. Animals of different taxonomic affiliations were used as test objects: (CBA × C57BI/6) F1 hybrid mice (Mus musculus) (warm-blooded organisms), Daphnia magna Straus (planktonic crustaceans) and the unicellular alga Chlorella vulgaris Beijer. In the study, we were guided by the test standards for acute oral toxicity and irritation to the skin, mucous membranes of the eyes and inhalation toxicity. The research results showed that the metabolites of the strain are not acutely toxic to organisms of different taxonomic levels. The metabolites of the strain do not have an irritating effect on the skin and mucous membranes of warm-blooded animals. Based on the studies carried out, metabolites can be used for creating a fungicidal biological preparation.
Highlights
In soil microbocenoses, pathogenic micromycetes cause various plant diseases and produce mycotoxins that cause acute and chronic intoxication when ingested by animals and humans
Based on the industrial strain of Streptomyces avermitilis, which is a producer of anthelmintic macrocyclic lactones, avermectins, a universal model recombinant was designed for the heterologous expression of genes encoding the biosynthesis of secondary metabolites
In order to exclude the toxic effect of the secondary metabolites of actinomycetes, there is a need to search for less toxic metabolites of actinomycetes
Summary
Pathogenic micromycetes cause various plant diseases and produce mycotoxins that cause acute and chronic intoxication when ingested by animals and humans. Scientific works provide evidence that fusariotoxins (FTs) contribute to the development of various diseases, provoke the growth of tumors and cause changes in plant metabolism, which leads to their death [1,2]. FTs have a multidirectional negative impact on all groups of organisms and are extremely dangerous. The monitoring and development of methods for suppressing the growth and development of these pathogens are necessary. One of these methods of suppression is the creation of biopesticides based on strains of actinomycetes [3–9]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
