Abstract
Magnesium and its alloys are not normally used as bioresorbable temporary implants due to their high and uncontrolled degradation rate in a physiological liquid environment. The improvement of corrosion resistance to simulated body fluids (SBF) of a magnesium alloy (AZ31) coated with poly-β-hydroxybutyrate (PHB) was investigated. Scanning electron microscopy, Fourier transform infrared spectrometer, and contact angle measurements were used to characterize surface morphology, material composition, and wettability, respectively. pH modification of the SBF corroding medium, mass of Mg2+ ions released, weight loss of the samples exposed to the SBF solution, and electrochemical experiments were used to describe the corrosion process and its kinetics. The material’s biocompatibility was described by evaluating the effect of corrosion by products collected in the SBF equilibrating solution on hemolysis ratio, cytotoxicity, nitric oxide (NO), and total antioxidant capacity (T-AOC). The results showed that the PHB coating can diffusively control the degradation rate of magnesium alloy, improving its biocompatibility: the hemolysis rate of materials was lower than 5%, while in vitro human umbilical vein endothelial cell (HUVEC) compatibility experiments showed that PHB-coated Mg alloy promoted cell proliferation and had no effect on the NO content and that the T-AOC was enhanced compared with the normal group and bare AZ31 alloy. PHB-coated AZ31 magnesium alloy extraction fluids have a less toxic behavior due to the lower concentration of corrosion byproducts deriving from the diffusion control exerted by the PHB coating films both from the metal surface to the solution and vice versa. These findings provide more reference value for the selection of such systems as tunable bioresorbable prosthetic materials.
Highlights
Biological implants have been widely used in various applications, and most of these biomedical devices are made from different biomaterials designed to stay permanently in the body
The surface of the thermally treated AZ31 magnesium alloy exhibits a relatively smooth surface withmagnesium snaking lines thatexhibits were probably due to the formation
AZ31 alloy a relatively of a nonhomogeneous magnesium hydroxide layer during the hydrothermal treatment
Summary
Biological implants have been widely used in various applications, and most of these biomedical devices are made from different biomaterials designed to stay permanently in the body. Several bioresorbable materials have been proposed to overcome these long-term limitations associated with permanent implant materials, and among these, magnesium is still attracting significant attention for its light weight, good mechanical properties, and compatibility with human physiology [5]. Another intriguing characteristic of magnesium is its osteoconductive activity, which has been described to occur in clinical trials as an increase of bone apposition in magnesiumbased implants [6]. The presence of Mg ions is a crucial cofactor for many enzymatic metabolic activities [6,7] Since early studies [7,8], it has been assessed that the presence of Mg structures for human bone fracture reduction decreases the time for hard callous formation.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.