Abstract
Numerous advances and innovative therapies have been introduced in interventional cardiology over the recent years, since the first introduction of balloon angioplasty, but bioresorbable scaffold is certainly one of the most exciting and attracting one. Despite the fact that the metallic drug-eluting stents have significantly diminished the re-stenosis ratio, they have considerable limitations including the hypersensitivity reaction to the polymer that can cause local inflammation, the risk of neo-atherosclerotic lesion formation which can lead to late stent failure as well as the fact that they may preclude surgical revascularization and distort vessel physiology. Bioresorbable scaffolds overcome these limitations as they have the ability to dissolve after providing temporary scaffolding which safeguards vessel patency. In this article we review the recent developments in the field and provide an overview of the devices and the evidence that support their efficacy in the treatment of CAD. Currently 3 devices are CE marked and in clinical use. Additional 24 companies are developing these kind of coronary devices. Most frequently used material is PLLA followed by magnesium.
Highlights
The need for Bioresorbable scaffolds Plain ‘old’ balloon angioplasty (POBA) was first performed by Andreas Roland Grüntzig in 1977 and heralded the first revolution in the percutaneous treatment of coronary artery disease (CAD) [1]
Despite the success in dilating and restoring coronary flow to diseased coronary vessels, enthusiasm to this ground-breaking technology was hampered by issues related to acute vessel closure secondary to iatrogenic coronary dissection and restenosis secondary to elastic recoil, constrictive remodelling, and neointimal hyperplasia [2,3,4,5]
Bare metal stents (BMS) heralded the second revolution in the treatment of CAD as means to overcome the limitations of POBA
Summary
The need for Bioresorbable scaffolds Plain ‘old’ balloon angioplasty (POBA) was first performed by Andreas Roland Grüntzig in 1977 and heralded the first revolution in the percutaneous treatment of coronary artery disease (CAD) [1]. Multicentre, non-randomized, Clinical Performance and Angiographic Results of Coronary Stenting with Absorbable Metal Stents (PROGRESS AMS) pilot study (63 patients with single de novo lesions, 71 AMS), no death, MI or stent thrombosis was reported at 12 months follow-up, with the treated vessel attaining its vasoreactivity within 4-months. A pilot study examining the efficacy of this device (15 patients, 19 lesions, 25 stents), demonstrated no MACE or ST within 30 days and only 1 repeat PCI at the 6-month follow-up.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
