Abstract
This paper reviews bioreactor related aspects of large scale plant cell technology for the production of biologically active compounds. Bioreactor designs currently in use are discussed with respect to specific operating parameters that can be varied to modulate cell growth and function in order to optimize product release and separation. Flow and mixing are recognized as key factors responsible for both the direct hydrodynamic effects on cell shape and function and flow induced changes in mass transfer of nutrients and metabolites. The integration of biosynthesis and separation is considered as a possible approach towards more efficient plant cell and tissue culture.
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