Bioprocess Modelling, Intensification, and Control

Abstract


 
 
 Chemical bio-process intensification, driven by the need for sustainability and cost-effectiveness, has gained significant attention. This study explores dynamic intensification (DI), a strategy to enhance efficiency by modifying system dynamics, operation, and control. Two key approaches are investigated: intensification by design, involving deliberate changes to physical and chemical aspects, and intensification by control, optimizing process parameters and feedback loops.
 The research focuses on the Optimal Periodic Control (OPC) method, dating back to the 1960s but now revisited with modern technology. To investigate the feasibility and effectiveness of dynamic intensification, a comprehensive methodology encompassing modeling, optimization, linearization, dynamic intensification, and control was designed. This methodology ensures systematic and standardized testing of DI in various bioprocesses within the industry.
 Through rigorous case studies, such as Activated Sludge Model No. 1 (ASM1) and an antibiotic perfusion bioreactor, the study demonstrates the practical benefits of dynamic intensification, including enhanced process efficiency and control. Applying model predictive control (MPC) further improves process efficiency, and the intensified systems are thoroughly compared to their respective base cases.
 The insights gained from this research contribute to advancements in bioprocessing technologies across industries, paving the way for sustainable and efficient engineering practices. Engineers can leverage this knowledge and the developed methodology to optimize chemical bioprocesses through innovative intensification strategies, ultimately promoting more eco-friendly and economical bio-processes. The study's comprehensive methodology offers valuable insights and understanding for bioprocess engineers seeking to enhance system efficiency and contribute to a greener future.