Abstract
Concepts: macromolecular adsorption - a brief introduction driving forces for protein adsorption at solid surfaces thermodynamics of adsorption of amino acids, small peptides, and nucleic acid components on silica adsorbents quantitative modelling of protein adsorption interfacial behaviour of protein mutants and variants. Methods: local and global optical spectroscopic probes of adsorbed proteins proteins on surfaces - methodologies for surface preparation and engineering protein function studies on the conformation of adsorbed proteins with the use of nanoparticle technology scanning calorimetry in probing the structural stability of proteins at interfaces ellipsometry and reflectometry for studying protein adsorption. Applications: interactions of proteins with polymeric synthetic membranes protein adsorption in intravenous drug delivery control of protein adsorption in solid-phase diagnostics and therapeutics protein interfacial behaviour in microfabricated analysis systems and microarrays protein adsorption in the oral environment adsorbed biopolymers - behaviour in food applications.
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