Abstract
A very cheap, naturally available, nontoxic and biopolymeric alginic acid has been found to be an efficient, recyclable and heterogeneous green catalyst for the Friedel–Crafts reactions of indoles at C-3 and C-2 positions with isoquinoline-1,3,4-triones and hydroxyindolyl derivatives in water under mild conditions. These operational simple procedures furnish good to high yields of corresponding synthetically as well as biologically interesting functionalized 4-hydroxy-4-indolylisoquinoline-1,3(2H,4H)-diones and 4,4-diindolylisoquinoline-1,3(2H,4H)-diones, respectively. Moreover, alginic acid could be recovered and reused several times (up to 5 times) without significant loss in activity.
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