Abstract
Introduction: Acute blunt or open renal trauma sometimes requires conservative measure which involves the use of specific materials in order to adequately restore renal parenchima. The purpose of this study is to analyze the effects of the sugar cane biopolymer sponge in an experimental model of renal trauma in rabbits. Methods: Experimental prospective study was paired with twelve New Zealand rabbits. After induction of renal trauma bilateral high-grade (grade 4-collecting system, according to AAST), the sugar cane biopolymer sponge was used for homeostasis and reconstruction of the right renal parenchyma (experimental group). The same procedure was performed in the left kidney, but using the Surgifoam? sponge (Control Group). The animals were sacrificed after four weeks. Histological analysis was performed and the results were compared after statistically being evaluated. Results: Comparing the experimental group with the control, there was more inflammatory reaction and premature adhesions in the first one. Concerning the influence on efficacy and biocompatibility of the biopolymer, no serious complications like massive bleeding, haematoma, fistula or urinary stone formation were found in both groups. Conclusion: The sugar cane biopolymer sponge demonstrated good efficacy in relation to hemostatic control and reconstruction of the renal parenchyma without major complications. Future studies may direct its routine use in urologic practice.
Highlights
Acute blunt or open renal trauma sometimes requires conservative measure which involves the use of specific materials in order to adequately restore renal parenchima
There are few reports in the literature on biomaterials and hemostatic fibrin sealants used as an aid in the reconstruction of damaged renal parenchyma [3,4]
We experimentally investigate the effects of Sugar Cane Biopolymer (SCB) in kidneys of rabbits with high grade surgical renal trauma
Summary
Acute blunt or open renal trauma sometimes requires conservative measure which involves the use of specific materials in order to adequately restore renal parenchima. The purpose of this study is to analyze the effects of the sugar cane biopolymer sponge in an experimental model of renal trauma in rabbits. After induction of renal trauma bilateral high-grade (grade 4-collecting system, according to AAST), the sugar cane biopolymer sponge was used for homeostasis and reconstruction of the right renal parenchyma (experimental group). Results: Comparing the experimental group with the control, there was more inflammatory reaction and premature adhesions in the first one. Conclusion: The sugar cane biopolymer sponge demonstrated good efficacy in relation to hemostatic control and reconstruction of the renal parenchyma without major complications. The kidney is the third most injured organ in the abdominal cavity in most cases following blunt trauma; 90% of cases are contusions or lacerations of the renal parenchyma smaller than 1 cm. There are few reports in the literature on biomaterials and hemostatic fibrin sealants used as an aid in the reconstruction of damaged renal parenchyma [3,4]
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