Biophysical Linkage between MRI and EEG Amplitude in Closed Head Injury

Abstract

Nuclear magnetic resonance of brain water proton (1H) T2 relaxation times and measures of absolute amplitude of EEG were obtained from 19 closed head injured patients. The relationship between EEG and T2 relaxation time differed as a function of both EEG frequency and gray matter versus white matter. White matter T2 relaxation time was positively correlated with increased EEG amplitude in the δ frequency band (0.5–3.5 Hz). In contrast, lengthened gray matter T2 relaxation time was inversely correlated with EEG amplitude in the α and β frequency bands (7–22 Hz). These findings are consistent with clinical EEG studies in which white matter lesions are related to increased EEG δ amplitude and gray matter lesions are related to decreased EEG α and β frequency amplitude. Estimates of the severity of injury were obtained by neuropsychological measurements, in which lengthened T2 relaxation times in both the neocortical gray and white matter were correlated with diminished cognitive function. Decreased EEG β and α amplitude and increased EEG δ amplitude were also correlated with diminished cognitive function. The findings imply a biophysical linkage between the state of protein–lipid structures of the brain as measured by the MRI and the scalp-recorded EEG.