Abstract
Background The immunogenic third variable region (V3) of HIV-1 gp120 is a target for AIDS vaccines. V3 is recognized by mAb 447-52D, known for its ability to neutralize viruses with a GPGR beta turn motif at the apex of V3, which is characteristic of clade B viruses. Interestingly, 447-52D can also bind non-clade B V3 peptides containing a GPGQ motif. A detailed biochemical and biophysical dissection of the antigen-antibody interaction of 447-52D was undertaken to understand this disparity.
Highlights
The immunogenic third variable region (V3) of HIV-1 gp120 is a target for AIDS vaccines
V3 is recognized by mAb 447-52D, known for its ability to neutralize viruses with a GPGR beta turn motif at the apex of V3, which is characteristic of clade B viruses
Of interactions and the salt bridge plays an important role in the affinity
Summary
The immunogenic third variable region (V3) of HIV-1 gp120 is a target for AIDS vaccines. Biophysical dissection of the antigen-antibody interaction of the broadly reactive anti-V3 human mAb 447-52D A Killikelly1*, H Zhang1, B Spurrier1, C Williams2, MK Gorny2, S Zolla-Pazner2, X Kong1 From AIDS Vaccine 2012 Boston, MA, USA. Background The immunogenic third variable region (V3) of HIV-1 gp120 is a target for AIDS vaccines.
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