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Abstract
Epilepsy is a common pediatric neurological disorder characterized by recurrent unprovoked seizures. SCN1A and SCN2A encode two neuronal voltage-gated sodium channels, namely NaV1.1 and NaV1.2 respectively, both of them highly expressed throughout the central nervous system (CNS). NaV1.1 localized within the axon initial segment (AIS) plays a critical role in the initiation and propagation of action potentials, predominantly in γ-aminobutyric acid (GABA)ergic neurons of the hippocampus. NaV1.2 is expressed in excitatory neurons with a steady increase and redistribution from AIS to distal axons.
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