Biophysical analysis of acute toxicity of radiotherapy in Hodgkin’s lymphoma — a comparison between extended field and involved field radiotherapy based on the data of the german hodgkin study group (GHSG)

Abstract

The correlation between complication probability and dose-volume histograms (DVHs) can be described with the linear-quadratic (LQ) model. The HD8 trial of the German Hodgkin Lymphoma Study Group (GHSG) for early-stage unfavourable Hodgkin’s lymphoma (HL) was designed to test whether radiotherapy (RT) can be reduced without loss of efficacy from extended field (EF) to involved field (IF) after two cycles of COPP alternating with two cycles of ABVD chemotherapy. Considering the number of side-effects that were found in the HD8 trial, we wanted to prove in this analysis, if biophysical parameters for the LQ-model could be determined.