Abstract
UV phototherapy [UVPT] has been used as an adjunct therapy for microbial infections. The molecular mechanisms contributing to UVPT remain unclear but are proposed to invoke elements of both microbial and inflammatory immunogenic mechanisms. The effectiveness of the Einstein Matrix of Blood Irradiation [EMBI] UVPT was determined in the treatment of antibiotic resistant S aureus infection [ARSI] in type II diabetic patients. Biochemical and cellular markers of immunomodulation, hematopoetic, and glycemic measures were obtained following EMBI UVPT. EMBI was accomplished via establishment of sterile autotransfusion, during which patient blood was exposed to calibrated bouts of UVA and/or UVC irradiation [96 seconds, 1.944 MJ, quartz cuvette] before reinfusion. ARSI was established via antimicrobial therapeutic failure and antibiotic sensitivity studies prior to EMBI. The effect of in vitro blood irradiation was without effect on morphological or biochemical parameters of hematopoesis and glycemia. In contrast, EMBI was associated with dose‐dependent decreases in expression of pro‐inflammatory cytokines (IL‐1p, IFN‐y and TNF‐a) mRNA expression and increases in mRNA expression of anti‐inflammatory Il‐b activity in mononuclear cells. These results are consistent with UVC induced modulation of immune responses to ARSI, in concert with direct effects of UVPT on microbial viability. Institute Support.
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