Biopharmaceutical study of general tonic capsules by in vitro method

Abstract

One of the main indicators of the quality of modern drugs are biopharmaceutical indicators, in particular, the “Dissolution” test - for solid dosage forms, as well as theoretical and experimental justification for the creation of new drugs and improvement of existing ones, taking into account the increase in their therapeutic effect and the reduction of side effects on organism. The article presents the results of research on the development of the “Dissolution” test for Indian ginseng, conducted at the Tashkent Pharmaceutical Institute. Determination of the dissolution rate of drugs from solid dosage forms is carried out on the device “Rotating basket”. To study the release rate of active substances from the analyzed encapsulated dosage form, the generally accepted method “Rotating basket” included in the XIV edition of the State Pharmacopoeia (SP XIV) was used. Based on the results of the experiments, the following conditions for determining the bioavailability of the analyzed capsules by the in vitro method were selected: to determine the dissolution profile, two dissolution media are used in succession - a 0.1 M solution of hydrochloric acid (capsules should not dissolve within 60 minutes) and - a phosphate buffer solution with pH 7 ,4 (at least 75% of the active substances should be released within 45 minutes), the volume of the medium is 1000 ml, the rotation speed of the basket is 100 rpm, the temperature regime is 37±10oC.