Bionic structure and blood compatibility of highly oriented homo-epitaxially crystallized poly(l-lactic acid)

Abstract

A highly oriented poly(l-lactic acid) (PLLA), with a blood vessel-like biomimetic structure, was fabricated using solid-phase hot drawing technology and homo-epitaxial crystallization to improve the mechanical properties and biocompatibility of PLLA. Long chain branched PLLA (LCB-PLLA) was prepared through a two-step ring-opening reaction, and a consequent draw as high as 1000 % was achieved during the hot drawing. The modulus and tensile strength were found to have increased through the formation of oriented shish-kebab like crystals along the drawing direction during processing. Furthermore, PLLA nano-lamellae were formed on the surface of the oriented plates via the introduction of homo-epitaxial crystallization. The high degree of orientation and epitaxial crystallization substantially enhanced the biocompatibility of the PLLA by prolonging clotting time, decreasing the rate of hemolysis, and increasing the cell growth and reproduction of the osteoblasts.