Abstract
The aim of this systematic review was to evaluate the application of potential therapeutic signaling molecules on complete dentin-pulp complex and pulp tissue regeneration in orthotopic and ectopic animal studies. A search strategy was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement in the MEDLINE/PubMed database. Animal studies evaluating the application of signaling molecules to pulpectomized teeth for pulp tissue or dentin-pulp complex regeneration were included. From 2530 identified records, 18 fulfilled the eligibility criteria and were subjected to detailed qualitative analysis. Among the applied molecules, basic fibroblast growth factor, vascular endothelial growth factor, bone morphogenetic factor-7, nerve growth factor, and platelet-derived growth factor were the most frequently studied. The clinical, radiographical and histological outcome measures included healing of periapical lesions, root development, and apical closure, cellular recolonization of the pulp space, ingrowth of pulp-like connective tissue (vascularization and innervation), mineralized dentin-like tissue formation along the internal dentin walls, and odontoblast-like cells in contact with the internal dentin walls. The results indicate that signaling molecules play an important role in dentin/pulp regeneration. However, further studies are needed to determine a more specific subset combination of molecules to achieve greater efficiency towards the desired tissue engineering applications.
Highlights
According to the General Assembly of the United Nations in September 2011, oral diseases are recognized as a major health burden for many countries
Even though many cell-based studies in animals, and few recently published in humans, have shown promising results in dentin-pulp regeneration, the potential risks and handling as well as the cost-related limitations of stem cell therapies, have led to a proposed shift towards the cell-free approach [45,46,47]
Our study evaluated the advantageous effect of applied signaling molecules to dentin-pulp complete regeneration in animal studies
Summary
According to the General Assembly of the United Nations in September 2011, oral diseases are recognized as a major health burden for many countries. During this meeting, a consensus was reached to include oral diseases in the common response to NonCommunicable Diseases (NCDs), as they share several common risk factors [1]. As part of the oral disease family, are not life-threatening and are mostly preventable. Their therapeutic management is a global health priority issue due to their very high prevalence. Considering the constant aging of the population in high/middle income countries, the prevalence of dental diseases is expected
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