Abstract

This paper introduces the concept of biomolecular characterization of inorganicsurfaces. The choice of biomolecule is discussed followed by techniques that can beused to analyse the quantity of bound species, strength of binding, the nature ofbinding sites, conformational changes and the layer morphology. The prospects ofmodelling this data using a combination of molecular dynamics simulation andprotein structural modelling and the correlation to measured data are outlined.The studies described in this paper are directed toward assessing thefeasibility of biomolecular characterization, however, the data collected inthe process are designed to also help elucidate our understanding of theinteraction between biomolecular species and inorganic materials interfaces.

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