Abstract
The current strategies for healing bone defects are numerous and varied. At the core of each bone healing therapy is a biomimetic mechanism, which works to enhance bone growth. These range from porous scaffolds, bone mineral usage, collagen, and glycosaminoglycan substitutes to transplanted cell populations. Bone defects face a range of difficulty in their healing, given the composite of dense outer compact bone and blood-rich inner trabecular bone. As such, the tissue possesses a number of inherent characteristics, which may be clinically harnessed as promoters of bone healing. These include mechanical characteristics, mineral composition, native collagen content, and cellular fraction of bone. This review charts multiple biomimetic strategies to help heal bony defects in large and small osseous injury sites, with a special focus on cell transplantation.
Highlights
Biomimetics and biomimicry are thought processes applied to biomaterial design, where materials meant for implantation have properties, which mirror closely those of natural material
This review will highlight the variety of biomimetic biomaterial research, with a specific focus on bone regeneration
As such, using FACS to select for BMPR-1b-positive cells from ASCs results in a population with increased osteogenic gene expression and in vitro osteogenic potential.[50]
Summary
Biomimetics and biomimicry are thought processes applied to biomaterial design, where materials meant for implantation have properties, which mirror closely those of natural material.
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