Abstract
The resemblance of nanofibers to the extracellular matrix (ECM) makes it suitable for various tissue engineering application. In this study, electro-spun polycaprolactone (PCL)-gelatin nanofibers had been fabricated with the incorporation thymoquinone (TQ) biomolecule as a periosteum substitute to promote regeneration of bone. The fabricated nanofibrous matrix possess osteo-conductive and osteo-inductive property. It is biocompatible and also acts as an excellent drug delivery vehicle. The significant expression of the bone matrix proteins, alkaline phosphatase secretion and calcium deposition studied in the MG-63 osteoblast like cells seeded on the nanofibrous matrix proves that it makes a suitable periosteum-substitute by enhancing bone mineralization.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
