Abstract
Ainsliatrimers A and B are two recently isolated complex sesquiterpenoid natural products that display the unprecedented chemical motifs and remarkable anti-cancer activities. The exact structures as well as the mechanism of anti-cancer action for ainsliatrimers A and B remain to be elucidated. Here we report the first concise and biomimetic syntheses of (−)-ainsliatrimers A and B. Our synthetic endeavor ultimately enabled the unambiguous structural assignments for these two stunningly complex trimers. Preliminary biological studies also revealed that ainsliatrimers A and B significantly inhibited cancer cell growth by inducing apoptosis.
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