Abstract
Glioblastoma multiforme (GBM) is a devastating type of tumor with high mortality, caused by extensive infiltration into adjacent tissue and rapid recurrence. Most therapies for GBM have focused on the cytotoxicity, and have not targeted GBM spread. However, there have been numerous attempts to improve therapy by addressing GBM invasion, through understanding and mimicking its behavior using three-dimensional (3D) experimental models. Compared with two-dimensional models and in vivo animal models, 3D GBM models can capture the invasive motility of glioma cells within a 3D environment comprising many cellular and non-cellular components. Based on tissue engineering techniques, GBM invasion has been investigated within a biologically relevant environment, from biophysical and biochemical perspectives, to clarify the pro-invasive factors of GBM. This review discusses the recent progress in techniques for modeling the microenvironments of GBM tissue and suggests future directions with respect to recreating the GBM microenvironment and preclinical applications.
Highlights
Malignant glioma, which is the most common primary brain tumor in adults, arises from star-shaped glial cells or their precursors within the central nervous system (Louis, 2006)
It is important to understand glioblastoma multiforme (GBM) invasion in brain tissue, to predict and evaluate tumor cell behavior; this is essential for developing new therapeutic inventions
This review focuses on recent research for biomimetic approaches to develop in vitro three-dimensional (3D) tumor models of glioblastoma cell invasion
Summary
Malignant glioma, which is the most common primary brain tumor in adults, arises from star-shaped glial cells or their precursors within the central nervous system (Louis, 2006). It is important to understand GBM invasion in brain tissue, to predict and evaluate tumor cell behavior; this is essential for developing new therapeutic inventions. This review focuses on recent research for biomimetic approaches to develop in vitro three-dimensional (3D) tumor models of glioblastoma cell invasion.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
