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Abstract
AbstractMost biological oxidations of exogenous compounds, such as drugs and endogenous compounds, especially when the hydroxylation of an inert C‐H bond is involved, are catalyzed by cytochrome P‐450‐dependent monooxygenases. These enzymes have the unique ability to transfer an oxygen atom from oxygen atom donors including O2 into almost any organic substrates including alkanes in a highly selective manner. Based on the knowledge of the mechanisms of substrate oxidation by these cytochromes, chemical model systems using metalloporphyrin catalysts have been built. In particular, a very efficient system for hydrocarbon oxidation by H2O2 in mild conditions is described. It is also shown that Fe‐ and Mn‐porphyrins catalyze the transfer of the NR nitrene moiety of PhI=NR compounds into hydrocarbons leading to direct aziridination of alkenes and amidation of alkanes with high yields.
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