Abstract
BackgroundNon-Hodgkin’s lymphoma (NHL) is a malignant disease of lymphoid tissue. At present, chemotherapy is still the main method for the treatment of NHL. R-CHOP can significantly improve the survival rate of patients. Unfortunately, DOX is the main cytotoxic drug in R-CHOP and it can lead to adverse reactions. Therefore, it is particularly important to uncover new treatment options for NHL.ResultsIn this study, a novel anti-tumor nanoparticle complex Nm@MSNs-DOX/SM was designed and constructed in this study. Mesoporous silica nanoparticles (MSNs) loaded with Doxorubicin (DOX) and anti-inflammatory drugs Shanzhiside methylester (SM) were used as the core of nanoparticles. Neutrophil membrane (Nm) can be coated with multiple nanonuclei as a shell. DOX combined with SM can enhance the anti-tumor effect, and induce apoptosis of lymphoma cells and inhibit the expression of inflammatory factors related to tumorigenesis depending on the regulation of Bcl-2 family-mediated mitochondrial pathways, such as TNF-α and IL-1β. Consequently, the tumor microenvironment (TME) was reshaped, and the anti-tumor effect of DOX was amplified. Besides, Nm has good biocompatibility and can enhance the EPR effect of Nm@MSNs-DOX/SM and increase the effect of active targeting tumors.ConclusionsThis suggests that the Nm-modified drug delivery system Nm@MSNs-DOX/SM is a promising targeted chemotherapy and anti-inflammatory therapy nanocomplex, and may be employed as a specific and efficient anti-Lymphoma therapy.
Highlights
Non-Hodgkin’s lymphoma (NHL) is a malignant disease of lymphoid tissue
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The results demonstrated that the combined application of DOX and Shanzhiside methylester (SM) inhibited the inflammation of tumor microenvironment and further enhanced the anti-tumor effect Neutrophil membrane (Nm)@MSNsDOX/SM nanocomplex has high drug loading, immune escape, anti-inflammatory, and anti-tumor activity, with a broad prospect of application
Summary
Non-Hodgkin’s lymphoma (NHL) is a malignant disease of lymphoid tissue. At present, chemotherapy is still the main method for the treatment of NHL. R-CHOP can significantly improve the survival rate of patients. DOX is the main cytotoxic drug in R-CHOP and it can lead to adverse reactions. Doxorubicin, vincristine, and prednisone (R-CHOP) can significantly improve the survival rate of patients [3]. DOX is the main cytotoxic drug in R-CHOP. Zhao et al J Nanobiotechnol (2021) 19:179 cardiotoxicity due to short half-life and non-specific distribution, limiting its clinical application [4]. Given these problems, nano-materials are loaded with chemotherapeutic drugs to improve the bioavailability of drugs and reduce the side effects of drugs [5]. Many different types of nanocarriers have been developed, such as inorganic mesoporous silica, quantum dots, metal nanoparticles, and liposomes [6]
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