Abstract
Magnetite (Fe3O4) nanoparticles are widely used in multiple biomedical applications due to their magnetic properties depending on the size, shape and organization of the crystals. However, the crystal growth and morphology of Fe3O4 nanoparticles remain difficult to control without using organic solvent or a high temperature. Inspired by the natural biomineralization process, a 14-mer bi-functional copolypeptide, leveraging the affinity of binding Fe3O4 together with targeting ovarian cancer cell A2780, was used as a template in the biomimetic mineralization of magnetite. Alongside this, a ginger extract was applied as an antioxidant and a size-conditioning agent of Fe3O4 crystals. As a result of the cooperative effects of the peptide and the ginger extract, the size and dispersibility of Fe3O4 were controlled based on the interaction of the amino acid and the ginger extract. Our study also demonstrated that the obtained particles with superparamagnetism could selectively be taken up by A2780 cells. In summary, the Fe3O4-QY-G nanoparticles may have potential applications in targeting tumor therapy or angiography.
Highlights
Fe3 O4 magnetic nanoparticles (Fe3 O4 -MNPs) have gradually become the concern of researchers because they can be applied in the fields of labeling, magnetic separation of biological materials, Magnetic Resonance Imaging (MRI) contrast enhancement, directed drug delivery, and hyperthermia treatment [1,2]
The nanoparticles retain no residual magnetism at room temperature with negligible coercivity, these particles could be dispersed when the magnetic field is removed, which is conducive to increasing the half-life of the particles in the circulation through escaping from macrophages
To verify that peptide TVNFKLY (TVN) could mediate the formation of Fe3 O4, Fe3 O4 -peptide nanoparticles were prepared using the method described in 4.2 with different concentrations of TVN and a random peptide named SVE
Summary
Fe3 O4 magnetic nanoparticles (Fe3 O4 -MNPs) have gradually become the concern of researchers because they can be applied in the fields of labeling, magnetic separation of biological materials, Magnetic Resonance Imaging (MRI) contrast enhancement, directed drug delivery, and hyperthermia treatment [1,2]. The properties and applications of Fe3 O4 -MNPs depend largely on size, crystallinity, and morphology. Fe3 O4 -MNPs could display a unique form of magnetism called superparamagnetism [3] when the diameter is below a certain size (generally 25–30 nm), which makes them respond more rapidly and stronger than the bulk magnets in a magnetic field [4]. The superparamagnetic Fe3 O4 -MNPs are oxidized in an aqueous solution, which would lead to reuniting. It is inevitable that some Fe3 O4 -MNPs obtained by one-pot method contain large amounts of organic
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