Abstract

The structure of membrane-active peptides and their interaction with lipid bilayerscan be studied in oriented lipid membranes deposited on solid substrates. Suchsystems are desirable for a number of surface-sensitive techniques. Here we focus onstructural characterization by x-ray and neutron reflectivity and give an accountof recent progress in sample preparation and measurements. We show that thedegree of mesoscopic disorder in the films can significantly influence the scatteringcurves. Static defects should be minimized by optimization of the preparationtechniques and their presence must be taken into account in the modelling. Examplesare given for alamethicin and magainin in bilayers of different phosphocholines.

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