Abstract
Biomimicry strategies, inspired by nature, are being widely used in the design of advanced biomaterials. Learning from the topographic landscape of natural bone resorption surface, which consists of micron/submicron-scale resorption lacunae and nano-scale sharp-tipped collagen fibrils, herein, a biomimetic fluoridated hydroxyapatite (FHA) coating composed of bilayer arrays of nanoneedles with micron/nano-topography was constructed on magnesium alloy surface via a microwave aqueous approach. The FHA coating possesses micron/submicron-scale roughness so as to mimic resorption lacunae. In parallel, the nanoneedles exhibit similar size and shape to collagen fibrils, especially their sharp tips. The surface topography, growth mechanism, osteogenic differentiation capacity and protection performance of this FHA coating were investigated. In vitro biological test showed that FHA coating significantly enhanced osteogenic differentiation capacity comprared with hydroxyapatite (HA) coating. Moreover, simulated body fluid immersion test demonstrated that FHA coating combined with formed HA mineralized layer together offered favorable long-term protection for magnesium alloy. This work may provide a new avenue of biomimetic surface topography design for orthopaedic implants with superior osteogenic differentiation capacity and corrosion resistance for long-term osseointegration of implants and fast bone regeneration.
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