Abstract
Developing microtissues that could promote bone regeneration remains a challenge. This study develops a biomimetic, biodegradable and osteoinductive microgel called 40% strontium-substituted hydroxyapatite/Microgel (40% Sr-HA/Microgel) to construct microtissues that could facilitate bone tissue regeneration. The open porous structure (with a pore diameter of 33 μm and porosity of 88%) of the 40% Sr-HA/Microgels could promote cellular proliferation and realize cell–cell interactions. The 40% Sr-HA/Microgels could stably release Sr2+ and show excellent osteoinductivity. In addition, the 40% Sr-HA/Microgels show outstanding biodegradable and injectable performances. Therefore, the 40% Sr-HA/Microgels could support the formation of microtissues to boost bone tissue regeneration. This study proposes an advanced microgel that could meet the need to form microtissues for bone tissue regeneration, thereby offering an accelerated therapeutic strategy for bone tissue engineering.
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