Abstract
An antithrombogenic electrochemical superoxide anion radical (O2•−) sensor was developed based on the concept of biomimetics. The sensor was fabricated by modification of a carbon microelectrode surface with polymerized iron 5,10,15,20-tetra(3-thienyl)porphyrin (FePor), followed by coating with a polyethylenedioxythiophene (PEDOT)/heparin or PEDOT/carboxymethyl dextran sulfate (CMDS) layer. The antithrombogenic superoxide anion radical sensors exhibited an amperometric oxidation current for O2•−, even after immersion of the sensor in bovine blood for 2 weeks, while the sensor without the PEDOT/heparin (or CMDS) layer had no response current after immersion in bovine blood for 1 h. The response current to 1 μM O2•− was almost constant at the PEDOT/CMDS-FePor-modified electrode after immersion in bovine blood for 1−14 days, and good linearity was observed in the concentration range between 0.52 and 1.80 μM, which is suitable sensitivity for the quantitative determination of O2•− in human blood. The PEDOT/CMDS-FePor-modified electrode contains no bio-derived compounds; therefore, its use as an antithrombogenic superoxide anion radical sensor should be safe, even when used in vivo.
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