Abstract
Osteoporosis is a skeletal disease characterized by bone loss and bone microarchitectural deterioration. The combination of smart materials and stem cells represents a new therapeutic approach. In the present study, highly porous scaffolds are prepared by combining the conducting polymer PEDOT:PSS with collagen type I, the most abundant protein in bone. The inclusion of collagen proves to be an effective way to modulate their mechanical properties and it induces an increase in scaffolds’ electrochemical impedance. The biomimetic scaffolds support neural crest-derived stem cell osteogenic differentiation, with no need for scaffold pre-conditioning contrarily to other reports.
Highlights
Osteoporosis affects more than 75 million patients in the EU, USA, and Japan with increasing prevalence correlating with the rising life expectancy
It is expected that the number of patients affected by these disorders will increase by a third by 2050.[1]. One of the recent innovative approaches to tackle osteoporosis entails the use of autologous stem cells in combination with a material that can actively influence their behavior
Biomimetic scaffolds that could be used to culture stem cells and induce their osteogenic differentiation
Summary
Osteoporosis affects more than 75 million patients in the EU, USA, and Japan with increasing prevalence correlating with the rising life expectancy. Biomimetic scaffolds that could be used to culture stem cells and induce their osteogenic differentiation.
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