Biomedicial therapeutic potential of copper tannic acid coordination nanosheet with multiple catalytic properties

Abstract

The utilization of nanomaterials in disease treatment has become a prominent area of research in the medical field. Nanocarrier materials endowed with catalytic and biological enzyme properties have exhibited promising prospects for applications in treating chronic inflammatory diseases, including cancer and diabetes. In this study, we have successfully synthesized a versatile CuTA nanosheets with a cost-effective approach, making it suitable for various pathological models. The CuTA nanosheets exhibit remarkable characteristics, including catalyzing the Fenton reaction for peroxide decomposition and accelerating the release of nitric oxide (NO) through the catalysis of endothelial nitric oxide synthase (eNOS), both of which are dependent on the concentration of the CuTA nanosheets. Furthermore, at a concentration of 2 mg/mL, the CuTA nanosheets achieved a removal rate of free radicals at 63.7%. When exposed to 808 nm near-infrared light, the temperature rose from 8 °C to 42 °C within 10 min. Additionally, at a concentration of 50 µg/mL, the inhibition rates of CuTA nanosheets on Escherichia coli and Staphylococcus aureus reached 98.3% and 96.1%, respectively. These unique characteristics make it highly suitable for effective applications in various fields, including biomedical, drug delivery, and photothermal therapy.