Biomedical Variables and Adaptation to Disease and Health-Related Quality of Life in Polish Patients with MS.

Joanna Dymecka,Mariola Bidzan

doi:10.3390/ijerph15122678

Abstract

The aim of this research was to assess the level of adaptation to multiple sclerosis (Sclerosis multiplex; MS) and health-related quality of life (HRQoL) of the study population as well as to determine the relationship between biomedical factors related to the course of multiple sclerosis, adaptation to the disease, and HRQoL. Analysis of medical records, clinical and psychological interviews, the Extended Disability Status Scale (EDSS), Guy’s Neurological Disability Scale (GNDS), the Acceptance of Illness Scale (AIS), and the Multiple Sclerosis Impact Scale 29 (MSIS-29) were collected from 137 patients with MS. It was found that there was a relation between motor impairment, neurological disability, adaptation to illness, and HRQoL; it was also found that there were negative correlations between adaptation to illness and the severity of lower-limb disability, fatigue, mood disorders, other problems related to MS, and upper-limb disability. Of all the symptoms, lower-limb disability, fatigue, and mood disorders had the strongest relation with adaptation. All of the analysed symptoms were found to correlate with HRQoL. Of all the symptoms, HRQoL was most affected by lower- and upper-limb disability, fatigue, other MS problems, and mood disorders.

Highlights

Multiple sclerosis (Sclerosis multiplex, MS) is a chronic, progressive, autoimmune central nervous system disease which affects the physical, mental, and social functioning of an individual [1,2]
The clinical manifestation of the disease is related to many neurological disorders, such as mobility problems, sensory and vision disturbances, sphincter disorders, fatigue, cognitive disorders, and mood disorders, which lead to the gradual development of disability
Characteristics of Biomedical Factors Associated with the Course of Multiple Sclerosis in the Multiple sclerosis is a clinically heterogeneous condition, and in its course, it can take several forms, the three main ones being: relapsing-remitting, primary-progressing, and secondary-progressive multiple sclerosis

Summary

Introduction

Multiple sclerosis (Sclerosis multiplex, MS) is a chronic, progressive, autoimmune central nervous system disease which affects the physical, mental, and social functioning of an individual [1,2]. It is one of the most common neurological disorders in young adults and the most common nontraumatic cause of disability among young and middle-aged individuals [3,4,5]. By destroying myelin sheaths and through axon degeneration in the brain and spinal cord, MS leads to permanent disability and its course is unpredictable and highly varied. MS may have a relapsing–remitting or chronically progressive form and may be mild or acute, as in the case of the Marburg variant

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