Abstract
In wound care management, the prevention of wound infection and the retention of an appropriate level of moisture are two major challenges. Therefore, designing an excellent antibacterial hydrogel with a suitable water-adsorbing capacity is very important to improve the development of wound dressings. In this paper, a novel silver nanoparticles/poly (gamma-glutamic acid) (γ-PGA) composite dressing was prepared for biomedical applications. The promoted wound-healing ability of the hydrogels were systematically evaluated with the aim of attaining a novel and effective wound dressing. A diffusion study showed that hydrogels can continuously release antibacterial factors (Ag). Hydrogels contain a high percentage of water, providing an ideal moist environment for tissue regeneration, while also preventing contraction of the wound. Moreover, an in vivo, wound-healing model evaluation of artificial wounds in mice indicated that silver/γ-PGA hydrogels could significantly promote wound healing. Histological examination revealed that hydrogels can successfully help to reconstruct intact epidermis and collagen deposition during 14 days of impaired wound healing. Overall, this research could shed new light on the design of antibacterial silver/γ-PGA hydrogels with potential applications in wound dressing.
Highlights
Skin is an indispensable natural barrier organ that protects internal organs from external environmental infection [1]
Microorganisms that enter the body can invade and begin to breed. This can lead to wound infection [2] and even life-threatening illnesses [3]
Wound care management is very difficult because infections may lead to exudate formation, which can lead to delayed wound healing and improper collagen deposition [4,5]
Summary
Skin is an indispensable natural barrier organ that protects internal organs from external environmental infection [1]. Wound care management is very difficult because infections may lead to exudate formation, which can lead to delayed wound healing and improper collagen deposition [4,5] Microorganisms, such as Staphylococcus aureus and Escherichia coli [6], are a major cause of infection. An ideal would dressing should possess biocompatible and antimicrobial properties to enhance wound healing, as well as a self-cleaning ability to prevent contamination [8,9]. To achieve this goal, researchers have developed different kinds of wet dressings. We designed a novel AgNpP with a poly(γ-glutamic acid) hydrogel, which could offer an accelerated wound regeneration environment with the release of the AgNpP antimicrobial factor
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