Abstract
A sulfated polysaccharide from tetrasporophyte tufts of Asparagopsis armata (Falkenbergia rufolanosa) (FRP) was extracted, then its structural, morphological and thermal properties were characterized. Antioxidant potential, enzymatic inhibitory effect and anticoagulant activities through activated partial thrombosis time, thrombin time and prothrombin time were also established. Additionally, this polymer was tested in vivo for its hepato-protective effect against toxicity induced by the fungicide — methyl thiophanate (MT). After MT injection, our data revealed a significant disruption in all biochemical and oxidative stress parameters associated with the hepatotoxicity features. Further, hepatic homogenates showed increased levels in inflammatory proteins consorted with detection of Bcl-2, IL-1beta, and P53 examined via immunohistochemistry revelation. These data were consolidate by liver histo-architecture and molecular investigation. However, the pre-treatment with FRP led to an effective healing process against MT's injuries. In summary, our data suggest that FRP could be assigned as a novel candidate for use as antioxidant, anticoagulant and hepato-protective agent.
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