Abstract
A pathological disorder of human penile function, known as Peyronie's disease, is characterized by the formation of plaque particles within the tunica albuginea. The plagues in the shape of rigid plate form in the scars as a result of the imperfect healing process. Due to high stiffness, plagues are the source of pain and anomalous deformations during erectile penis function. The authors simulate the biomechanical behavior of the penile structure by a 3D finite element model. The numerical model is based on the real geometrical shape and the tissue structure with consideration of large nonlinear deformations. The penile erection is modeled by the initial strains imposed on the corpus cavernosa. The stress analysis is performed in a case study of various plague locations. The Peyronie's syndrome manifested by the penis angular deviation simulated by the analysis is compared with the clinical data. The computational simulations provide a rational explanation for the clinical observations on patients. The objective is to apply the proposed modeling approach for the development and validation of treatment methods based on the application of shock waves.
Highlights
Peyronie’s disease is characterized by a fibrous rigid scar or indurated area in the tunica albuginea causing penile pain and penile curvature during erection, reducing the possibility of intercourse
Attempts to explain the pathogenesis and etiology of this frustrating disease are dated from the 13th century
An alternative approach was chosen, in which the erectile action is simulated by the imposed strains on the corpus cavernosa body
Summary
Peyronie’s disease is characterized by a fibrous rigid scar (plaque) or indurated area in the tunica albuginea causing penile pain and penile curvature during erection, reducing the possibility of intercourse. It includes the corpus cavernosa as a driving agent of the erection and the tunica albuginea as a resisting ligament. The erectile function demarcated by the penis deformation is driven by the volume expansion of the corpus cavernosa, considered as a loading effect by the imposed initial strain. This approach is different from the other approaches described in the literature ([2, 3], Timm et al 2008 [4]). The numerical simulation was made using the commercial software ATENA (Cervenka et al [5])
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