Abstract
ObjectivesThe aim of this study was to evaluate the effect of TiO2 nanoparticles on the mechanical and anti-ageing properties of a medical silicone elastomer and to assess the biocompatibility of this novel combination. MethodsTiO2 (P25, Degussa, Germany) nanoparticles were mixed with the silicone elastomer (MDX4-4210, Dow Corning, USA) at 2%, 4%, and 6% (w/w) using silicone fluid as diluent (Q7-9180, Dow Corning, USA). Blank silicone elastomer served as the control material. The physical properties and biocompatibility of the composites were examined. The tensile strength was tested for 0% and 6% (w/w) before and after artificial ageing. SEM analysis was performed. ResultsTiO2 nanoparticles improved the tensile strength and Shore A hardness of the silicone elastomer (P<0.05). However, a decrease in the elongation at break and tear strength was found for the 6% (w/w) composite (P<0.05). All the ageing methods had no effect on the tensile strength of the 6% (w/w) composite (P>0.05), but thermal ageing significantly decreased the tensile strength of the control group (P<0.05). Cellular viability assays indicated that the composite exhibited biocompatibility. ConclusionsWe obtained a promising restorative material which yields favourable physical and anti-ageing properties and is biocompatible in our in vitro cellular studies.
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