Biomechanical and histomorphometric evaluation of a thin ion beam bioceramic deposition on plateau root form implants: An experimental study in dogs

Abstract

The aim of this study was to evaluate the biomechanical fixation, bone-to-implant contact, and bone morphology of an ion beam assisted deposition of a 300-500 nm thick Ca- and P-based bioceramic surface on a previously alumina-blasted/acid-etched Ti-6Al-4V implant surface in a dog model. Thirty-six 4.5 x 11 mm plateau root form implants, control (alumina-blasted/acid-etched-AB/AE) and test groups (AB/AE+300-500 nm bioceramic coating, Nanotite) were placed along a proximal tibia of six beagle dogs remaining for 2 and 4 weeks (n = 3 animals per implantation time). Following euthanization, the implants were torqued to interface fracture at approximately 0.196 radians/sec until a 10% maximum load drop was detected. The implants in bone were nondecalcified processed to approximately 30 microm thickness slides for histomorphologic and bone-to-implant contact (BIC) assessment. Statistical analyses for torque to interface fracture were performed using a mixed model ANOVA, and BIC was evaluated by the chi2 test at 95% level of significance. At 4 weeks, significantly higher torque to interface fracture was observed for the Test implant surface. Histomorphologic analysis showed higher degrees of bone organization for test implants compared to control at 2 and 4 weeks. Significantly higher BIC was observed at 4 weeks compared to 2 weeks (no statistical differences between control and test implants). The higher torque to interface fracture and increased bone maturity obtained in this study support that the surface modification comprising a 300-500 nm Ca- and P-based bioceramic coating positively influenced healing around pleateau root form implants.