Biomechanical analysis of yeast cell based a piezoresistive cantilever sensor

Abstract

The biomechanical properties (Young's Modulus, stiffness, adhesion force) is important for the cell micro/nano manipulation. In this article, a piezoresistive cantilever sensor is suitable for measuring quantitatively Young's Modulus of a single yeast cell because of some advantage of high sensitivity, dynamic response, simple structure, low cost. For calibrating a piezoresistive cantilever's elastic coefficient, it is carried out through the setup designed. Between the force, the cantilever tip deflection and the output voltage follow a good linear relationship. Analyzing the recorded force curves by applying Hertz-Sneddon model allows the extraction of cell mechanical properties Young's Modulus. Young's Modulus is realized for measuring single yeast cell, yielding young's modulus values of 2.9 ± 2.2Mpa. The result indicates that Young's Modulus measured both by a piezoresistive cantilever and AFM precise can be in good consistency of order of magnitude. Investigations aiming a description of micro/nanoforce measuring of the piezoresistive cantilever sensor are conducted in micro/nano manipulation.