Abstract
Over the past two decades in situ tissue engineering has emerged as a new approach where biomaterials are used to harness the body’s own stem/progenitor cells to regenerate diseased or injured tissue. Biomaterials are designed to recruit resident stem cells to pathological or injured tissue sites and direct them towards tissue regeneration. This review explores advances gathered from in vitro and in vivo studies on in situ tissue regenerative therapies. Here we also examine the different ways this approach has been incorporated into biomaterial sciences in order to create customized biomaterial products for therapeutic applications in a broad spectrum of tissues and diseases.
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