Abstract
This chapter focuses on biopolymer scaffolds as cell carriers and their beneficial effects in improving neural stem/progenitor cell therapies for stroke repair. Biopolymers offer a flexible tool to design an integrative solution for stroke repair and address multiple limitations of cell therapy in stroke. We describe important chemical and biophysical properties of biopolymers that contribute to their beneficial effects. We then discuss how cellular scaffolds promote stem/progenitor cell survival and differentiation. Integration of transplanted cells to the host tissue is crucial for any therapeutic with promising functional benefit. Therefore, the chapter continues by describing inherent or engineered characteristics of biopolymer networks that promote integration in stroke repair. The chapter concludes by a review of published reports on biopolymer cell combinations for stroke repair and a few notes regarding the clinical translation of biopolymer scaffolds in cell therapies for stroke.
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