Abstract
Exposure to high concentrations of oxygen radicals, the lack of nucleus and mitochrondria, inability to synthesise new protein and degradation of detoxifying enzymes makes red blood cells (RBCs) uniquely vulnerable to oxidative stress. This review summarizes the changes in biochemical parameters that primarily contribute to alterations in red blood cells during oxidative stress. PubMed, Science Direct and Springer online databases and updates from the Indian Council of Medical Research (ICMR). As one of the first cells to be affected by changes in the redox status of the body, alterations in red blood cells are widely used in first step-diagnoses of a number of pathological conditions. The information presented in this review provides an update on biomarkers of redox balance in red blood cells. These biomarkers may be used for assessment of oxidative stress during human health and disease.
Highlights
Red blood cells (RBCs) are unique, highly specialized and the most abundant cells in the human organism. Their primary function is transportation of the respiratory gases, O and CO, between lungs and tissues, these circulatory cells are equipped with effective anti-oxidative systems that make them mobile free radical scavengers, providing antioxidant protection to themselves and to other tissues and organs in the body[1,2]
The present review focuses on red blood cell biomarkers which can be used as measures of oxidative stress
Oxygen radicals and other reactive species, generated tion of enzymes in red blood cells lead to develop- as by-products of aerobic metabolism and through expoment of various human diseases
Summary
Exposure to high concentrations of oxygen radicals, the lack of nucleus and mitochrondria, inability to synthesise new protein and degradation of detoxifying enzymes makes red blood cells (RBCs) uniquely vulnerable to oxidative stress. This review summarizes the changes in biochemical parameters that primarily contribute to alterations in red blood cells during oxidative stress
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