Biomarkers of Oxidative Stress in Polycystic Ovary Disorder

Abstract

Background: oxidative stress(OS) happens when harmful reactive oxygen species (ROS) exceed antioxidants leading to damage of lipid, protein and DNA. OS was documented to participate in pathogenesis and complication of polycystic ovary syndrome(PCOS). PCOS is a common endocrine disorder, with incidence 4-12% between female at fertility period that leads to anovulation and infertility. This syndrome is accompanied with over production of androgen and dysfunction of ovaries which are associated by classical signs and/or symptoms and biochemical characteristics comprising hirsutism, acne, ultrasonic feature of polycystic ovaries, irregular menstrual period, adiposity, dyslipidemia, decrease insulin sensitivity and prediabetes. Aim of the Study: to evaluate biomarkers levels of oxidative stress in women with PCOS and in healthy control women. This evaluation is necessary to show the effect of oxidative stress on sex hormonal profile of women with PCOS. Participants and Methods: thirty women (16-38 year) with PCOS and thirty matched age women were enrolled to evaluate oxidative status by measuring serum levels of malondialdehyde(MDA) concentration and total antioxidant capacity(TAC) in all participants. Results: Women with Polycystic ovary exhibited significantly increased means of MDA levels and significantly decreased mean of TAC levels when compared to healthy participants. Conclusion: it concluded from this study there is a disturbance of oxidant and antioxidant profile in PCO women supposes a status of oxidative stress, guided by high level of oxidative stress biomarker of lipid peroxidation (MDA) and decreased antioxidant defense mechanism which indicated by TAC. Moreover, the oxidative stress biomarkers can be employed as indicator in early diagnosis of PCOS and utilization of them in monitoring and preventing further complication of it.