Abstract
Both host and viral factors are associated with HIV-1 susceptibility and disease progression. Host factors can typically be divided into three categories (Chatterjee, 2010): 1) genes encoding cell-surface receptors or ligands for these proteins, including the classic CCR5 32-bp deletion; 2) genes within the human leukocyte antigens (HLA) that regulate host responses to infection; and 3) other cytokine and immune response genes, including the homozygosity at position −308 in the TNF-alpha promoter.
Highlights
HIV-1 viral protein R (Vpr) is a multifunctional virion-associated accessory protein (Cohen et al, 1990)
Vpr is critical in the viral replication cycle in non-dividing cells, such as monocytes (Connor et al, 1995), whereas it has been shown to be dispensable in T-lymphocytes (Eckstein et al, 2001)
This host factor, MRJ-L, is the large splice isoform of DNAJB6 and the authors state that it has been shown to interact with Vpr, this data, to date has not been published and this point is in need of further detailed exploration
Summary
HIV-1 viral protein R (Vpr) is a multifunctional virion-associated accessory protein (Cohen et al, 1990). Plex, and following nuclear import Vpr likely plays a major role in regulating the expression of immediate-early HIV-1 genes from the integrated proviral genome. In the manuscript by Chiang et al within this issue of EBioMedicine, a new host factor is described as playing a role in HIV-1 susceptibility (Chiang et al, 2014).
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
