Biomarkers of Gut Microbiota in Chronic Spontaneous Urticaria and Symptomatic Dermographism.

Runqiu Liu,Jianglin Zhang,Jie Li,Danrong Jing,Shuang Zhao,Yangjian Xiao,Cong Peng,Xiang Chen,Wu Zhu

doi:10.3389/fcimb.2021.703126

Abstract

BackgroundChronic urticaria (CU) is a chronic inflammatory skin disease associated with Th2 immune response. The two most common subtypes of CU, i.e., chronic spontaneous urticaria and symptomatic dermographism (CSD), often coexist. However, the pathogenesis of CSD is still unclear. Gut microbiota plays an important role in immune-related inflammatory diseases. The purpose of this study was to explore the correlation between gut microbiota and CSD.MethodsA case-control study was conducted on CSD patients as well as gender- and age-matched normal controls (NCs). The 16S ribosomal DNA sequencing of fecal samples was used to detect the gut microbiota of all subjects. QPCR was used to further verify the species with differences between the two groups.ResultsThe alpha diversity of gut microbiota decreased in CSD patients, accompanied by significant changes of the structure of gut microbiota. Subdoligranulum and Ruminococcus bromii decreased significantly in CSD patients and had a potential diagnostic value for CSD according to receiver operating characteristic curve (ROC) analysis. Enterobacteriaceae and Klebsiella were found to be positively correlated with the duration of CSD, while Clostridium disporicum was positively correlated with the dermatology life quality index (DLQI).ConclusionsThe gut microbiota of CSD patients is imbalanced. Subdoligranulum and Ruminococcus bromii are the gut microbiota biomarkers in CSD.

Highlights

Chronic urticaria (CU), a common recurrent inflammatory skin disease with an incidence rate of 0.1% to 1.4% (Fricke et al, 2020), has a serious impact on the work, study, quality of life and mental health of patients, and imposes a huge economic and social burden to the family and society (Itakura et al, 2018; Zuberbier et al, 2018; Goncalo et al, 2020)
Subdoligranulum and Ruminococcus bromii decreased significantly in chronic spontaneous urticaria and symptomatic dermographism (CSD) patients and had a potential diagnostic value for CSD according to receiver operating characteristic curve (ROC) analysis
Enterobacteriaceae and Klebsiella were found to be positively correlated with the duration of CSD, while Clostridium disporicum was positively correlated with the dermatology life quality index (DLQI)

Summary

Introduction

Chronic urticaria (CU), a common recurrent inflammatory skin disease with an incidence rate of 0.1% to 1.4% (Fricke et al, 2020), has a serious impact on the work, study, quality of life and mental health of patients, and imposes a huge economic and social burden to the family and society (Itakura et al, 2018; Zuberbier et al, 2018; Goncalo et al, 2020). The two most common subtypes of CU, i.e., chronic spontaneous urticaria and symptomatic dermographism (CSD), often coexist. The purpose of this study was to explore the correlation between gut microbiota and CSD

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Results

Conclusion