Abstract
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmias and associated with the risk of stroke and death. Continuous development of the diagnostic tool and prognostic stratification may lead to optimal management of AF. The use of biomarkers in the management of AF has been grown as an interesting topic. However, the AF biomarkers are not yet well established in the major guidelines. Among these biomarkers, a lot of data show troponin and brain natriuretic peptides are promising for the prediction of future events. The troponin elevation in AF patients may not necessarily be diagnosed as myocardial infarction or significant coronary artery stenosis, and brain natriuretic peptide elevation may not necessarily confirm heart failure. Troponin T and troponin I may predict postoperative AF. Furthermore, troponin and brain natriuretic peptide gave better prognostic performance when compared with the risk score available today.
Highlights
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in clinical practice and known as an independent risk factor for stroke [1]. e available data suggest that AF presence affects deaths up to twofold higher [2]
Troponin I was taken before CABG and postoperatively at ICU admission. e postoperative troponin level was lower in the sinus rhythm group compared to the AF group (0.66 ± 1.66 vs 2.07 ± 5.01 ng/ml, p 0.029). e ROC was 0.901 ng/ml, which was the best cutoff value for predicting AF within hospitalization. e calculated area under curve was 0.71
Parwani et al [29] found that AF patients with a high rate and/or ischemic symptoms frequently associated with troponin I (TnI) elevation presented in the emergency
Summary
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in clinical practice and known as an independent risk factor for stroke [1]. e available data suggest that AF presence affects deaths up to twofold higher [2]. Biomarkers have been playing significant role as risk predictors and prognostic values of some cardiovascular diseases, but it seems that AF is not one of them due to the Cardiology Research and Practice lack of information for the use of biomarkers in the management of AF itself [5]. Histological and electrical change in atrial fibrillation occurred due to multiple factors that include inflammation, oxidative stress, renin angiotensin, growth factor, and ionchannel dysfunction, and even adipose tissue plays a substantial role for the development of AF through its paracrine effect [11]. Is review will give information of biomarkers in the development, risk prediction, and prognostic value of the AF according to the recent published studies Histological and electrical change in atrial fibrillation occurred due to multiple factors that include inflammation, oxidative stress, renin angiotensin, growth factor, and ionchannel dysfunction, and even adipose tissue plays a substantial role for the development of AF through its paracrine effect [11]. is review will give information of biomarkers in the development, risk prediction, and prognostic value of the AF according to the recent published studies
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